I personally don't experience it, but my players say that the D&D4e character sheet lags pretty badly. Edit: I'm thinking that it has to do with the sheer size of the D&D4E sheet. It's 1.3MB and ~22000 lines of code. The next one that even comes close to that is the D&D5E sheet which is 291KB and ~5500 lines of code. I've cut that down to 720 KB by cutting the number of powers down from 100 to 50, but that still puts the sheet a good 400 KB ahead of anything else. When downloading a file 400 KB isn't much, but I assume that the Roll20 character sheet environment is different.