If you are referring to Roll20 voice capabilities then yes, there is the ability to mute your own mic or mute someone else from being heard by you. The key, as far as I can tell, is having the same browser used by all users. Win7 or higher will clear up a lot of issues. Someone who has a slow/poor connection will still drop on occasion, but NOT having Skype hogging system resources helps cut processing lag. I would suggest seeing if youequipment as the GM can work with the system, then add one player at a time to see who is compatible and who isnt. Headsets are a must unless you love echo/feed back.