Ran our first real session last night. Myself in win7+chrome as gm, other players in win7, win8, or Mac, and in firefox, chrome or safari.
After fooling with audio for a while, we gave up and switched to ventrilo. It worked fine for me, but one of my players couldn't hear another one, though I could hear both of them.
Generally love it (great work guys), the map sharing is smooth and without significant lag. the video worked fine for us when some of us tried it but we decided to turn it off to save bandwidth.
Few thoughts
1) As GM, I'd love some visual indicator of what layer I'm on.
2) I expected to be able to drag players to the map and have tokens appear. I was confused when that didn't work and it took me a while to realize that it wasn't a bug.
3) like someone else said, I expected to be able to scroll-wheel zoom the map and kept trying it even after I'd leaned it doesn't work.
4) many of the things that I thought "why can't I do this?" about turned out to be possible but buried in options and never mentioned in help (that I could find)
5) I like the look of the dynamic lighting effect, but I'd really just like a round brush to erase or add "fog of war"
Love the videos you've done, but I find myself wanting one where you demonstrate how to set up and actually play something with commentary about how you're using the software to support the play. I found my computer cluttered with rule books, maps, character sheets, etc. I rapidly ran out of screen space and switching resources all the time wasn't smooth. I.e. my workspace was poorly optimized.