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Trying to figure if I want to run a Fantasy or a Sci-Fi DnD session

As A DM, I'm trying to figure out if I would rather DM a Sci Fi session or a Fantasy session, tough I am unsure on which one to actually go with.
first question is what edd of dnd? if 3.x I would love to play a sandboxy style fantasy. If sci fi I haven't played d20 modern/future in a long time.
5e