I run a decent amount of one-offs in 4e. I think it works really well actually. I do agree with Trollkin though that pre-gen characters are the way to go. A lot of times one-off's are appealing to new players so that is a big help there too. Generally, my one offs are just dungeon delves with everything mapped out ahead of time, and a boss at the end. I have three or four that I just will reuse for different groups. Also, I haven't tried it yet, but an idea I am toying with is just keeping everyone "in combat" the whole time... forcing them to move their speed, like a board game and allowing short rest healing surges after combat.