At least partially yes. Ya gotta have roll20 subscription to use API scripts. keithcurtis of this forum, is the author of the best Card Deck related API scripts, available "in the One-Click". The !commands for that API can be saved as Macros, and does as-much-things as Roll20 allows the API to do with cards so far, and YES i believe that would include Remove Card from a Player's Hand. The documentation for his API will answer this for-sure.