It works fantastically. My group and I played SR pretty heavily on it for months, though we switched games for a while just before the updated macro mechanics went live. In theory it should be a little easier now. I did a little guide for playing Shadowrun on Roll 20 - you can find it by going to help & Docs and then "system Specific guides" on the menu on the right. Theoretically the new macro system should make it even easier, but I've not tested it out fully. I'd recommend making a complete character sheet with every attribute, skill and common macro, then duplicating it for each new player and NPC. It takes a lot longer at first, but it'll really pay off. I suspect that you can also set up one of the little token bars to be a dice modifier and then call that in your macros, so you'd have /roll (@Str+@Unarmed+@Modifier)d6>5 . Last time I tried this, it didn't like negative modifiers, but that might have changed.