Best way to handle skill checks

I recently found out about Roll20, and I want to use it to run a campaign this summer with some friends who want to play tabletop but live in different places. So far i've mostly been tinkering with the system to figure out how it all works. I've got the basics, for the most part, but I'm not sure what's the most efficient way to handle skill rolls. Should I have the players make macros for each skill, and update them manually when they add skill points, or treat all their skills as attributes and use macros based off those, or just keep their skills on separate character sheets and have them do "/r d20+x" whenever they do a skill check, or something different I haven't thought of? I know this is probably a really basic question, but I looked around and haven't found much about it. Thanks in advance!

The last one you said. Players can also set up macros if they feel inclined. Both are very easy to do but have the same result.

I find it is easiest to just roll a straight-up d20 macro (or whatever other commonly rolled die for that game), add the modifier mentally, and say the result verbally. You could make macros for each skill and tie it to an attribute so that when you level it's easier to adjust, but some games have a lot of skills that could easily take up your whole macro bar. My rule of thumb is that if it takes longer to type out a roll command (or find a macro in your list) than it does to pick up an actual die and roll it, then the technology is actually getting in the way. Just about nothing's worse than waiting a long time for someone to flip through their sheet, type a roll command, and then see it come up 1. :)

It all depends on how you want to do things. If you find it goes faster to roll a d20 and add the modifiers in your head then go that route. If you find that your players use standardized predetermined attacks then making the macros would be the way to go. Making the macros depends on what you want to do like Iserith says in the first paragraph.

It does depend on what you want to do as Metroknight says. If you plan to use the chat to keep a record of what people did in game then there is a value in setting up some Abilities. I like having emotes followed by the roll in the relevant ability.  e.g.  /em tries to deflect the blow    /r 1d100<65 Parry If your system allows frequent skill upgrades then you can use an Attribute for the skill target. Some players seem to prefer putting frequently used abilities on the quick bar. This makes who is rolling and what for really easy to pick out in the record. If you don't need or want the text chat in Roll20 then type /r D20 or use the dice roller GUI.