An API script won't directly slow down your game (it's running on the server, not locally), and a truly misbehaving script will get its rate throttled to protect other people's API scripts (all on the same server) from getting caught up. The most likely worst-case of having too many API scripts in a campaign trying to do too many things is that the responsiveness of the scripts will go down (or the script will simply crash). Non-script aspects of the campaign should remain unaffected. If you're packing a ton of stuff into your campaign, you're more likely to get hammered for having dozens upon dozens of characters and handouts and images (especially large images) than due to something your API scripts are doing.