I like more of the improvisational, storytelling kind like Fate than the more number crunchy types. But I also "grew up" on DnD so I still like that style of play too. I've heard of other systems I would love to try too like Kids on Bikes, Everyone is John, Adventures in Middle Earth, and Paranoia.
As for settings, I think I am open to almost all settings except ones with horror, gore or mature content as a main aspect of the game. I would most enjoy fantasy, Star Wars, and steampunk.