I'm running Google Chrome on Windows Vista SP3, for reference.
While running Roll20 as the DM for a few friends, I experimented with the Jukebox feature. After selecting a song from the list of available ones, setting it, and hitting play, my microphone stopped working within Roll20 (it continued to work just fine outside of it on Teamspeak) and would not function again until after a refresh.
Hope that's enough info to help in your investigating of the bug.
I'm a huge fan of all the other features so far, so keep up the good work!