Here are a few things that i have found to be useful: Have house rules and what source books are allowed/disallowed typed up as either a handout or as the background of the map to avoid confusion. Have information about the setting that might be relevant ready as handouts. This varies by game, but might include: a world map, information about organisations or religions in your setting, where the campaigns starting point will be, any backstory/lore that the characters need to know. Have some tokens ready to go: Having some art work ready to use as character tokens is useful. this artwork might be replaced pretty quickly, but it allows you to create tokens to use in the meantime. Be familiar with the character sheet for your system, it really helps to know the sheet so you can help your players if they have questions. Run it like you would a regular session. The goal of a VTT is to enhance your game, but don't let those enhancements bog you down. Run things as you otherwise would, making use of features that you think would be benneficial